{"id":15058,"date":"2022-12-22T19:36:10","date_gmt":"2022-12-22T18:36:10","guid":{"rendered":"https:\/\/www.immuninlab.ch\/?page_id=15058"},"modified":"2026-11-09T12:28:19","modified_gmt":"2026-11-09T11:28:19","slug":"auto-anticorps","status":"publish","type":"page","link":"https:\/\/www.immuninlab.ch\/fr\/prestations\/auto-anticorps\/","title":{"rendered":"Auto-anticorps"},"content":{"rendered":"<div class=\"wpb-content-wrapper\" id=\"wpb-content-root\"><p>[vc_row][vc_column][vc_toggle title=&#8221;D\u00e9pistage des collag\u00e9noses (anticorps anti-nucl\u00e9aires (ANA) et anti-cytoplasmiques)&#8221;]<strong>Objectif du test<\/strong><\/p>\n<p>Mesurer les auto-anticorps associ\u00e9s aux collag\u00e9noses. Les collag\u00e9noses sont des maladies rhumatismales inflammatoires syst\u00e9miques dont l&#8217;\u00e9volution est g\u00e9n\u00e9ralement chronique (maladies syst\u00e9miques du tissu conjonctif). Chaque collag\u00e9nose se caract\u00e9rise par des profils d&#8217;auto-anticorps typiques. Les collag\u00e9noses comprennent :<\/p>\n<ul>\n<li>Lupus \u00e9ryth\u00e9mateux diss\u00e9min\u00e9 (LED)<\/li>\n<li>Syndrome de Sj\u00f6gren (SjS)<\/li>\n<li>Scl\u00e9rose syst\u00e9mique (SSc)<\/li>\n<li>Myosites idiopathiques (auto-immunes)<\/li>\n<li>Collag\u00e9nose mixte (Mixed connective tissue disease, MCTD, ou syndrome de Sharp)<\/li>\n<li>Syndrome de chevauchement (overlap syndrome)<\/li>\n<\/ul>\n<p><strong>Auto-anticorps mesur\u00e9s \u00e0 l&#8217;aide du d\u00e9pistage des anticorps anti-nucl\u00e9aires et anti-cytoplasmiques :<\/strong><\/p>\n<ul>\n<li><strong>Auto-anticorps anti-ADNdb<\/strong><\/li>\n<li><strong>Auto-anticorps anti-histone<\/strong><\/li>\n<li><strong>Auto-anticorps anti-nucl\u00e9osome (anti-chromatine)<\/strong><\/li>\n<li><strong>Auto-anticorps anti-Sm<\/strong><\/li>\n<li><strong>Auto-anticorps anti-prot\u00e9ines-P ribosomales (anti-P0, anti-P1, anti-P2)<\/strong><\/li>\n<li><strong>Auto-anticorps anti-PCNA<\/strong><\/li>\n<li><strong>Auto-anticorps anti-U1nRNP (sous-unit\u00e9s A, C et 68 kDa)<\/strong><\/li>\n<li><strong>Auto-anticorps anti-SSA<\/strong><\/li>\n<li><strong>Auto-anticorps anti-SSB<\/strong><\/li>\n<li><strong>Auto-anticorps anti-Scl70 (anti-topoisom\u00e9rase I)<\/strong><\/li>\n<li><strong>Auto-anticorps anti-CENP-B (anti-centrom\u00e8re B)<\/strong><\/li>\n<li><strong>Auto-anticorps anti-Jo-1<\/strong><\/li>\n<li><strong>Auto-anticorps anti-Mi-2<\/strong><\/li>\n<li><strong>Auto-anticorps anti-PM\/Scl (anticorps associ\u00e9s au syndrome de chevauchement polymyosite\/scl\u00e9rodermie)<\/strong><\/li>\n<li><strong>Auto-anticorps anti-Ku<\/strong><\/li>\n<li><strong>Auto-anticorps anti-mitochondries M2 (AMA) (sous-unit\u00e9s E2 PDC, BCOADC et OGDC)<\/strong><\/li>\n<\/ul>\n<p><strong>Fr\u00e9quence<\/strong><\/p>\n<p>Quotidienne<\/p>\n<p><strong>Unit\u00e9 de mesure<\/strong><\/p>\n<p>Titre (immunofluorescence indirecte sur cellules HEp-2 fix\u00e9es)<br \/>\nUnit\u00e9s relatives (UR) ou unit\u00e9s internationales (UI) pour les auto-anticorps anti-ADNdb.<\/p>\n<p><strong>Plages de r\u00e9f\u00e9rence<\/strong><\/p>\n<p>Titre &lt; 1:80<br \/>\n&lt; 1 unit\u00e9 relative (UR)<\/p>\n<p><strong>Points tarifaires<\/strong><\/p>\n<table border=\"1\">\n<thead>\n<tr>\n<th>Auto-anticorps<\/th>\n<th>Position<\/th>\n<th>P.tarifaires<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Auto-anticorps anti-noyau cellulaire (auto-anticorps<br \/>\nantinucl\u00e9aires, ANA) (qn)<\/td>\n<td>1191.10<\/td>\n<td>45.00<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-ADNdb (qn)<\/td>\n<td>1112.00<\/td>\n<td>46.80<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-histone (ql)<\/td>\n<td>1129.00<\/td>\n<td>33.30<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-nucl\u00e9osome (1er auto-anticorps rare) (ql)<\/td>\n<td>1192.00<\/td>\n<td>46.80<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-Sm (ql)<\/td>\n<td>1173.00<\/td>\n<td>15.10<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-prot\u00e9ine-P ribosomale (2e auto-anticorps rare) (ql)<\/td>\n<td>1192.00<\/td>\n<td>46.80<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-PCNA (ql)<\/td>\n<td style=\"text-align: center;\">&#8211;<\/td>\n<td>gratuit<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-RNP (ql)<\/td>\n<td>1169.00<\/td>\n<td>15.10<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-SSA\/Ro (ql)<\/td>\n<td>1181.00<\/td>\n<td>15.10<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-SSB\/La (ql)<\/td>\n<td>1183.00<\/td>\n<td>15.10<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-Scl70 (ql)<\/td>\n<td>1171.00<\/td>\n<td>15.10<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-centrom\u00e8res (ql)<\/td>\n<td>1105.00<\/td>\n<td>33.30<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-Jo1, histidyl-ARNt synth\u00e9tase (ql)<\/td>\n<td>1139.00<\/td>\n<td>18.90<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-Mi-2 (3e auto-anticorps rare) (ql)<\/td>\n<td>1193.00<\/td>\n<td>33.30<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-PM-Scl (4e auto-anticorps rare) (ql)<\/td>\n<td>1193.00<\/td>\n<td>33.30<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-Ku (5e auto-anticorps rare) (ql)<\/td>\n<td>1193.00<\/td>\n<td>33.30<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-mitochondries M2 (ql)<\/td>\n<td>1149.00<\/td>\n<td>19.80<\/td>\n<\/tr>\n<tr>\n<td>TOTAL<\/td>\n<td><\/td>\n<td>466.10<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Domaine de laboratoire : Immunologie<\/p>\n<p><strong>ANALYTIQUE<\/strong><\/p>\n<p><strong>M\u00e9thode<\/strong><\/p>\n<p>Immunofluorescence indirecte sur cellules HEp-2 fix\u00e9es<br \/>\nSpotimmunoassay (SIA), d\u00e9tection des auto-anticorps IgG antinucl\u00e9aires et<br \/>\ncytoplasmiques[\/vc_toggle][vc_toggle title=&#8221;D\u00e9pistage des maladies auto-immunes du foie&#8221;]<strong>Objectif du test<\/strong><\/p>\n<p>Mesure des auto-anticorps associ\u00e9s aux maladies auto-immunes du foie. Apr\u00e8s exclusion d\u2019une \u00e9tiologie virale, la d\u00e9tection d&#8217;auto-anticorps dirig\u00e9s contre des antig\u00e8nes h\u00e9patiques sp\u00e9cifiques est essentielle pour diagnostiquer les maladies h\u00e9patiques auto-immunes. Parmi les maladies auto-immunes du foie, on distingue l&#8217;h\u00e9patite auto-immune (HAI) de type I et II et la cholangite biliaire primitive (CBP). Des syndromes de chevauchement de l&#8217;HAI et de la CBP sont \u00e9galement connus.<\/p>\n<p>Anticorps mesur\u00e9s par le d\u00e9pistage des maladies auto-immunes du foie :<\/p>\n<p><strong>Anticorps associ\u00e9s \u00e0 l&#8217;h\u00e9patite auto-immune :<\/strong><\/p>\n<ul>\n<li><strong>Auto-anticorps anti-actine F<\/strong><\/li>\n<li><strong>Auto-anticorps anti-SLA<\/strong><\/li>\n<li><strong>Auto-anticorps anti-LKM1<\/strong><\/li>\n<li><strong>Auto-anticorps anti-LC1<\/strong><\/li>\n<\/ul>\n<p><strong>Anticorps associ\u00e9s \u00e0 la cholangite biliaire primitive :<\/strong><\/p>\n<ul>\n<li><strong>Auto-anticorps anti-mitochondries (anticorps anti-M2, AMA) (sous-unit\u00e9s E2 PDC, BCOADC et OGDC)<\/strong><\/li>\n<li><strong>Auto-anticorps anti-gp210<\/strong><\/li>\n<li><strong>Auto-anticorps anti-Sp100<\/strong><\/li>\n<\/ul>\n<p><strong>Fr\u00e9quence<\/strong><\/p>\n<p>Quotidienne<\/p>\n<p><strong>Unit\u00e9 de mesure<\/strong><\/p>\n<p>Unit\u00e9s relatives (UR)<\/p>\n<p><strong>Plages de r\u00e9f\u00e9rence<\/strong><\/p>\n<p>&lt; 1 unit\u00e9 relative (UR)<\/p>\n<p><strong>Points tarifaires<\/strong><\/p>\n<table border=\"1\">\n<thead>\n<tr>\n<th>Auto-anticorps<\/th>\n<th>Position<\/th>\n<th>P.tarifaires<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Auto-anticorps anti-actine F (ql)<\/td>\n<td>1097.00<\/td>\n<td>33.30<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-antig\u00e8nes solubles h\u00e9patiques (SLA) (ql)<\/td>\n<td>1175.00<\/td>\n<td>19.80<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-antig\u00e8nes des microsomes h\u00e9patiques et r\u00e9naux (LKM) (ql)<\/td>\n<td>1147.00<\/td>\n<td>33.30<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps contre l\u2019antig\u00e8ne 1 du cytosol h\u00e9patique (LC1) (ql)<\/td>\n<td style=\"text-align: center;\">&#8211;<\/td>\n<td>gratuit<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-mitochondries (ql)<\/td>\n<td>1157.00<\/td>\n<td>33.30<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-gp210 (1er auto-anticorps rare) (ql)<\/td>\n<td style=\"text-align: left;\">1192.00<\/td>\n<td>46.80<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-Sp100 (2e auto-anticorps rare) (ql)<\/td>\n<td>1192.00<\/td>\n<td>46.80<\/td>\n<\/tr>\n<tr>\n<td>TOTAL<\/td>\n<td><\/td>\n<td>213.30<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Domaine de laboratoire\u00a0: Immunologie<\/p>\n<p><strong>ANALYTIQUE<\/strong><\/p>\n<p><strong>M\u00e9thode<\/strong><\/p>\n<p>Spotimmunoassay (SIA), d\u00e9tection des auto-anticorps IgG[\/vc_toggle][vc_toggle title=&#8221;D\u00e9pistage des vasculites (ANCA-screen &#8211; Auto-anticorps anti-cytoplasme des neutrophiles)&#8221;]<strong>Objectif du test<\/strong><\/p>\n<p>Mesure des auto-anticorps associ\u00e9s aux vasculites des petits vaisseaux. Des l\u00e9sions se forment dans les petits vaisseaux \u00e0 la suite d&#8217;un processus inflammatoire provoqu\u00e9 par les ANCA. La mesure des anticorps impliqu\u00e9s dans les vasculites des petits vaisseaux (anti-PR3, anti-MPO et anti-MBG) est une <u>analyse d&#8217;urgence<\/u>.<\/p>\n<p>Les principaux auto-anticorps associ\u00e9s aux ANCA :<\/p>\n<ul>\n<li>Anti-PR3 (anti-prot\u00e9inase 3)<\/li>\n<li>Anti-MPO (anti-my\u00e9loperoxydase)<\/li>\n<\/ul>\n<p>Syndrome de Goodpasture :<\/p>\n<ul>\n<li>Anti-MBG (anti-membrane basale glom\u00e9rulaire)<\/li>\n<\/ul>\n<p><strong>Auto-anticorps mesur\u00e9s par l\u2019ANCA-screen :<\/strong><\/p>\n<ul>\n<li><strong>Immunofluorescence indirecte sur les neutrophiles<\/strong><\/li>\n<li><strong>Auto-anticorps anti-PR3<\/strong><\/li>\n<li><strong>Auto-anticorps anti-MPO<\/strong><\/li>\n<li><strong>Auto-anticorps anti-MBG<\/strong><\/li>\n<\/ul>\n<p><strong>Fr\u00e9quence<\/strong><\/p>\n<p>Quotidienne<\/p>\n<p><strong>Unit\u00e9 de mesure<\/strong><\/p>\n<p>Titre (immunofluorescence indirecte sur neutrophiles fix\u00e9s)<br \/>\nUnit\u00e9s relatives (UR) (anti-PR3, anti-MPO et anti-MBG)<\/p>\n<p><strong>Plages de r\u00e9f\u00e9rence<\/strong><\/p>\n<p>Titre &lt; 1:80<br \/>\n&lt; 1 unit\u00e9 relative (UR)<\/p>\n<p><strong>Points tarifaires<\/strong><\/p>\n<table border=\"1\">\n<thead>\n<tr>\n<th>Auto-anticorps<\/th>\n<th>Position<\/th>\n<th>P.tarifaires<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Auto-anticorps anti-cytoplasme des neutrophiles (ANCA), screening et typisation des p-ANCA\/c-ANCA\/ANCA atypiques<\/td>\n<td>1161.10<\/td>\n<td>46.80<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps ANCA anti-prot\u00e9inase 3 (PR3-ANCA)<\/td>\n<td>1110.00<\/td>\n<td>25.20<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps ANCA anti-my\u00e9loperoxydase (MPO-ANCA)<\/td>\n<td>1109.00<\/td>\n<td>25.20<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-membrane basale glom\u00e9rulaire<\/td>\n<td>1124.00<\/td>\n<td>46.80<\/td>\n<\/tr>\n<tr>\n<td>TOTAL<\/td>\n<td><\/td>\n<td>144.00<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Domaine de laboratoire : Immunologie<\/p>\n<p><strong>ANALYTIQUE<\/strong><\/p>\n<p><strong>M\u00e9thode<\/strong><\/p>\n<p>Immunofluorescence indirecte sur neutrophiles fix\u00e9s<br \/>\nSpotimmunoassay (SIA), d\u00e9tection des auto-anticorps IgG[\/vc_toggle][vc_toggle title=&#8221;D\u00e9pistage des myosites auto-immunes (myopathies inflammatoires idiopathiques)&#8221;]<\/p>\n<p><strong>Objectif du test<\/strong><\/p>\n<p>Mesure des auto-anticorps associ\u00e9s aux myopathies inflammatoires idiopathiques (MII). Les MII sont des maladies auto-immunes rares des muscles squelettiques qui touchent souvent aussi la peau et les poumons ; environ 10 % des cas sont associ\u00e9s \u00e0 une n\u00e9oplasie. Les anticorps sp\u00e9cifiques des myosites (MSA) d\u00e9finissent des sous-groupes cliniques ; en r\u00e8gle g\u00e9n\u00e9rale, un seul MSA est pr\u00e9sent. Les anticorps associ\u00e9s aux myosites (MAA) s\u2019observent aussi dans d\u2019autres maladies auto-immunes pouvant chevaucher une myosite et peuvent s\u2019ajouter \u00e0 un MSA. Les myopathies inflammatoires idiopathiques comprennent :<\/p>\n<ul>\n<li>Dermatomyosite (DM), y compris la DM amyopathique et la DM sine dermatitis<\/li>\n<li>Polymyosite (PM)<\/li>\n<li>Myosite \u00e0 inclusions (Inclusion Body Myositis, IBM)<\/li>\n<li>Myopathie n\u00e9crosante auto-immune (MNAI)<\/li>\n<li>Syndrome des antisynth\u00e9tases (SAS)<\/li>\n<li>Syndromes de chevauchement (myosite de chevauchement)<\/li>\n<\/ul>\n<p><strong>Auto-anticorps mesur\u00e9s \u00e0 l\u2019aide du d\u00e9pistage des myosites auto-immunes :<\/strong><\/p>\n<p><strong>Anticorps associ\u00e9s \u00e0 la dermatomyosite :<\/strong><\/p>\n<ul>\n<li>Auto-anticorps anti-Mi-2\u03b1 et anti-Mi-2\u03b2 \u2013 manifestations cutan\u00e9es typiques, \u00e9volution g\u00e9n\u00e9ralement b\u00e9nigne<\/li>\n<li>Auto-anticorps anti-TIF1\u03b3 \u2013 l\u00e9sions cutan\u00e9es marqu\u00e9es ; forte association avec un cancer chez l\u2019adulte ; marqueur le plus fr\u00e9quent de la MII juv\u00e9nile<\/li>\n<li>Auto-anticorps anti-MDA5 \u2013 DM amyopathique avec pneumopathie interstitielle (PID) rapidement progressive<\/li>\n<li>Auto-anticorps anti-NXP2 \u2013 myosite s\u00e9v\u00e8re, ulc\u00e9rations cutan\u00e9es, calcinose ; risque accru de cancer chez l\u2019adulte<\/li>\n<li>Auto-anticorps anti-SAE1 \u2013 d\u00e9but g\u00e9n\u00e9ralement amyopathique, myosite secondaire<\/li>\n<\/ul>\n<p><strong>Anticorps associ\u00e9s au syndrome des antisynth\u00e9tases (myosite, PID, arthrite, mains de m\u00e9canicien) :<\/strong><\/p>\n<ul>\n<li>Auto-anticorps anti-Jo-1 (histidyl-ARNt synth\u00e9tase)<\/li>\n<li>Auto-anticorps anti-PL-7 (thr\u00e9onyl-ARNt synth\u00e9tase)<\/li>\n<li>Auto-anticorps anti-PL-12 (alanyl-ARNt synth\u00e9tase)<\/li>\n<li>Auto-anticorps anti-EJ (glycyl-ARNt synth\u00e9tase)<\/li>\n<li>Auto-anticorps anti-OJ (isoleucyl-ARNt synth\u00e9tase)<\/li>\n<li>Auto-anticorps anti-Ha (tyrosyl-ARNt synth\u00e9tase)<\/li>\n<li>Auto-anticorps anti-Ks (asparaginyl-ARNt synth\u00e9tase)<\/li>\n<li>Auto-anticorps anti-Zo (ph\u00e9nylalanyl-ARNt synth\u00e9tase)<\/li>\n<\/ul>\n<p><strong>Anticorps associ\u00e9s \u00e0 la myopathie n\u00e9crosante auto-immune :<\/strong><\/p>\n<ul>\n<li>Auto-anticorps anti-SRP (signal recognition particle) \u2013 myosite aigu\u00eb et s\u00e9v\u00e8re sans atteinte cutan\u00e9e<\/li>\n<\/ul>\n<p><strong>Anticorps associ\u00e9s \u00e0 la myosite \u00e0 inclusions :<\/strong><\/p>\n<ul>\n<li>Auto-anticorps anti-cN-1A (5\u2019-nucl\u00e9otidase cytosolique 1A)<\/li>\n<\/ul>\n<p><strong>Anticorps associ\u00e9s aux myosites (syndromes de chevauchement) :<\/strong><\/p>\n<ul>\n<li>Auto-anticorps anti-Ku<\/li>\n<li>Auto-anticorps anti-PM-Scl100<\/li>\n<li>Auto-anticorps anti-PM-Scl75<\/li>\n<li>Auto-anticorps anti-Ro-52 (TRIM21) \u2013 non sp\u00e9cifiques d\u2019une maladie<\/li>\n<\/ul>\n<p><strong>Fr\u00e9quence<\/strong><\/p>\n<p>Tous les jours<\/p>\n<p><strong>Unit\u00e9 de mesure<\/strong><\/p>\n<p>Aucune<\/p>\n<p><strong>Plages de r\u00e9f\u00e9rence<\/strong><\/p>\n<p>N\u00e9gatif (intensit\u00e9 du signal de 0 \u00e0 10 ; les valeurs de 6 \u00e0 10 sont consid\u00e9r\u00e9es comme limites, mais encore n\u00e9gatives)<\/p>\n<p>Positif (intensit\u00e9 du signal &gt; 10 : +, ++, +++), r\u00e9sultat positif \u00e9galement indiqu\u00e9 par l&#8217;intensit\u00e9 mesur\u00e9e \u00e0 l&#8217;aide d&#8217;un scanner.<\/p>\n<p><strong>Points tarifaires<\/strong><\/p>\n<table border=\"1\">\n<thead>\n<tr>\n<th>Auto-anticorps<\/th>\n<th>Position<\/th>\n<th>P.tarifaires<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Auto-anticorps, rares<\/td>\n<td>1194.00<\/td>\n<td>78.3<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps, rares<\/td>\n<td>1194.00<\/td>\n<td>78.3<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps, rares<\/td>\n<td>1195.00<\/td>\n<td>60.3<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps, rares<\/td>\n<td>1195.00<\/td>\n<td>60.3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Domaine de laboratoire : Immunologie<\/p>\n<p><strong>ANALYTIQUE<\/strong><\/p>\n<p><strong>M\u00e9thode<\/strong><\/p>\n<p>Immunoblot sur bandelettes (line blot) EUROLINE myopathies inflammatoires auto-immunes (EUROIMMUN), \u00e9valuation automatis\u00e9e par EUROLineScan. D\u00e9tection des auto-anticorps IgG dirig\u00e9s contre 20 antig\u00e8nes.<\/p>\n<p>[\/vc_toggle][vc_toggle title=&#8221;D\u00e9pistage de la scl\u00e9rodermie syst\u00e9mique (auto-anticorps associ\u00e9s \u00e0 la ScS)&#8221;]<\/p>\n<p><strong>Objectif du test<\/strong><\/p>\n<p>Mesure des auto-anticorps associ\u00e9s \u00e0 la scl\u00e9rodermie syst\u00e9mique (ScS). La ScS est une maladie auto-immune rare caract\u00e9ris\u00e9e par une dysfonction microvasculaire et une fibrose de la peau et des organes internes : ph\u00e9nom\u00e8ne de Raynaud, scl\u00e9rodactylie, pneumopathie interstitielle (PID), hypertension art\u00e9rielle pulmonaire (HTAP), troubles de la motilit\u00e9 digestive et crise r\u00e9nale. Plus de 95 % des patients pr\u00e9sentent des anticorps antinucl\u00e9aires. Les auto-anticorps sp\u00e9cifiques de la ScS sont associ\u00e9s \u00e0 l\u2019\u00e9tendue de l\u2019atteinte cutan\u00e9e et aux atteintes d\u2019organes ; les anticorps anti-centrom\u00e8re, anti-Scl-70 et anti-ARN polym\u00e9rase III font partie des crit\u00e8res de classification ACR\/EULAR 2013. Le d\u00e9pistage permet en outre de distinguer les aspects nucl\u00e9olaires des ANA sp\u00e9cifiques de la ScS de ceux qui ne le sont pas. Les formes de scl\u00e9rodermie syst\u00e9mique comprennent :<\/p>\n<ul>\n<li>ScS cutan\u00e9e limit\u00e9e<\/li>\n<li>ScS cutan\u00e9e diffuse<\/li>\n<li>ScS sine scleroderma<\/li>\n<li>Syndromes de chevauchement (p. ex. ScS\/myosite)<\/li>\n<\/ul>\n<p><strong>Auto-anticorps mesur\u00e9s \u00e0 l\u2019aide du d\u00e9pistage de la scl\u00e9rodermie syst\u00e9mique :<\/strong><\/p>\n<ul>\n<li>Auto-anticorps anti-Scl-70 (ADN topoisom\u00e9rase I) \u2013 surtout ScS diffuse, PID fr\u00e9quente ; chez environ 40 % des patients<\/li>\n<li>Auto-anticorps anti-CENP-A et anti-CENP-B (anti-centrom\u00e8re) \u2013 surtout ScS limit\u00e9e, risque accru d\u2019HTAP ; chez environ 30 %<\/li>\n<li>Auto-anticorps anti-ARN polym\u00e9rase III (sous-unit\u00e9s RP11 et RP155) \u2013 ScS diffuse avec \u00e9paississement cutan\u00e9 rapidement progressif ; crise r\u00e9nale, estomac past\u00e8que (GAVE) et cancers plus fr\u00e9quents ; environ 15 %<\/li>\n<li>Auto-anticorps anti-fibrillarine (U3-RNP) \u2013 atteinte s\u00e9v\u00e8re des organes (PID, HTAP, cardiomyopathie, crise r\u00e9nale) ; 5 \u00e0 10 %<\/li>\n<li>Auto-anticorps anti-NOR90 \u2013 ScS limit\u00e9e et diffuse ; &lt; 5 %<\/li>\n<li>Auto-anticorps anti-Th\/To \u2013 surtout ScS limit\u00e9e avec PID et HTAP ; environ 5 %<\/li>\n<li>Auto-anticorps anti-PM-Scl100 et anti-PM-Scl75 \u2013 surtout syndromes de chevauchement ScS\/myosite ; environ 7 \u00e0 10 %<\/li>\n<li>Auto-anticorps anti-Ku \u2013 surtout ScS limit\u00e9e et chevauchement ScS\/polymyosite ; &lt; 5 %<\/li>\n<li>Auto-anticorps anti-NVL (nuclear valosin-containing protein-like) \u2013 rares, environ 1 %<\/li>\n<li>Auto-anticorps anti-Ro-52 (TRIM21) \u2013 non sp\u00e9cifiques d\u2019une maladie<\/li>\n<\/ul>\n<p><strong>Fr\u00e9quence<\/strong><\/p>\n<p>Tous les jours<\/p>\n<p><strong>Unit\u00e9 de mesure<\/strong><\/p>\n<p>Aucune<\/p>\n<p><strong>Plages de r\u00e9f\u00e9rence<\/strong><\/p>\n<p>N\u00e9gatif (intensit\u00e9 du signal de 0 \u00e0 10 ; les valeurs de 6 \u00e0 10 sont consid\u00e9r\u00e9es comme limites, mais encore n\u00e9gatives)<\/p>\n<p>Positif (intensit\u00e9 du signal &gt; 10 : +, ++, +++), r\u00e9sultat positif \u00e9galement indiqu\u00e9 par l&#8217;intensit\u00e9 mesur\u00e9e \u00e0 l&#8217;aide d&#8217;un scanner<\/p>\n<p><strong>Points tarifaires<\/strong><\/p>\n<table border=\"1\">\n<thead>\n<tr>\n<th>Auto-anticorps<\/th>\n<th>Position<\/th>\n<th>P.tarifaires<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Auto-anticorps anti-centrom\u00e8res<\/td>\n<td>1106.00<\/td>\n<td>46.8<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps anti-Scl70<\/td>\n<td>1172.00<\/td>\n<td>25.2<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps, rares<\/td>\n<td>1194.00<\/td>\n<td>78.3<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps, rares<\/td>\n<td>1194.00<\/td>\n<td>78.3<\/td>\n<\/tr>\n<tr>\n<td>Auto-anticorps, rares<\/td>\n<td>1195.00<\/td>\n<td>60.3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Domaine de laboratoire : Immunologie<\/p>\n<p><strong>ANALYTIQUE<\/strong><\/p>\n<p><strong>M\u00e9thode<\/strong><\/p>\n<p>Immunoblot sur bandelettes (line blot) EUROLINE profil scl\u00e9rodermie syst\u00e9mique 2 (EUROIMMUN), \u00e9valuation automatis\u00e9e par EUROLineScan. D\u00e9tection des auto-anticorps IgG dirig\u00e9s contre 13 antig\u00e8nes.<\/p>\n<p>[\/vc_toggle][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_toggle title=&#8221;D\u00e9pistage des collag\u00e9noses (anticorps anti-nucl\u00e9aires (ANA) et anti-cytoplasmiques)&#8221;]Objectif du test Mesurer les auto-anticorps associ\u00e9s aux collag\u00e9noses. Les collag\u00e9noses sont des maladies rhumatismales inflammatoires syst\u00e9miques dont l&#8217;\u00e9volution est g\u00e9n\u00e9ralement chronique [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":14961,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-15058","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t<meta name=\"description\" content=\"Analyses d\u2019auto-anticorps chez Immuninlab : d\u00e9pistage des collag\u00e9noses, des maladies auto-immunes du foie et ANCA. 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